Detalhe da pesquisa
1.
The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7.
J Biol Chem
; 300(5): 107144, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38458397
2.
Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.
Nucleic Acids Res
; 50(22): 13045-13062, 2022 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36537190
3.
Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.
EMBO Rep
; 22(12): e53693, 2021 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34661367
4.
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.
Proc Natl Acad Sci U S A
; 117(29): 17195-17203, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32606248
5.
EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
J Cell Sci
; 133(9)2020 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184261
6.
Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.
Nat Chem Biol
; 11(7): 496-503, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030730
7.
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.
Mol Cell
; 36(4): 560-70, 2009 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19941817
8.
Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.
Cell Mol Life Sci
; 73(6): 1209-24, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755435
9.
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical ß-propeller domain.
Proc Natl Acad Sci U S A
; 111(14): 5195-200, 2014 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24706829
10.
Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.
Proc Natl Acad Sci U S A
; 111(27): 9840-5, 2014 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24958871
11.
Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction.
J Cell Sci
; 127(Pt 11): 2493-506, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695856
12.
EML proteins in microtubule regulation and human disease.
Biochem Soc Trans
; 44(5): 1281-1288, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27911710
13.
A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.
Malar J
; 15(1): 535, 2016 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27821169
14.
A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.
Mol Cell
; 32(4): 576-83, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19026787
15.
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.
Biochem J
; 467(3): 529-36, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25740311
16.
Poc1A and Poc1B act together in human cells to ensure centriole integrity.
J Cell Sci
; 126(Pt 1): 163-75, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23015594
17.
Mutation of POC1B in a severe syndromic retinal ciliopathy.
Hum Mutat
; 35(10): 1153-62, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25044745
18.
The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.
Hum Mol Genet
; 21(5): 1155-71, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22106379
19.
Cell cycle regulation by the NEK family of protein kinases.
J Cell Sci
; 125(Pt 19): 4423-33, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23132929
20.
Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.
J Cell Sci
; 125(Pt 22): 5353-68, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22956538